Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor
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چکیده
منابع مشابه
Inhibition of growth of Chlamydia trachomatis by human gamma interferon.
Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (greater th...
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The immunoregulatory effects of transforming growth factor beta (TGF-beta) and recombinant murine tumor necrosis factor alpha (rMuTNF-alpha) on CTL generation and activity were examined. The results demonstrate that TGF-beta, in a dose-dependent manner, inhibited CTL generation but not CTL activity. The inhibitory effects were detected only when TGF-beta was added within the first 48 h of the M...
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The role of TNF-alpha in muscle catabolism is well established, but little is known about the mechanisms of its catabolic action. One possibility could be that TNF-alpha impairs the production of local growth factors like IGF-I. The aim of this study was to investigate whether TNF-alpha can directly inhibit IGF-I gene and protein expression in muscle. First, we investigated whether the acute in...
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Fernández-Celemı́n, Laura, Nevi Pasko, Valérie Blomart, and Jean-Paul Thissen. Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor. Am J Physiol Endocrinol Metab 283: E1279–E1290, 2002. First published July 2, 2002; 10.1152/ajpendo.00054.2002.—The role of TNFin muscle catabolism is well established, but little is known about the mechanisms of its catabolic actio...
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Tumor necrosis factor-alpha (TNF-alpha) has a key role in skeletal disease in which it promotes reduced bone formation by mature osteoblasts and increased osteoclastic resorption. Here we show that TNF inhibits differentiation of osteoblasts from precursor cells. TNF-alpha treatment of fetal calvaria precursor cells, which spontaneously differentiate to the osteoblast phenotype over 21 days, in...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1988
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.56.9.2503-2506.1988